Endocrine Abstracts

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Obesity is defined as an excess of adipose tissue of sufficient magnitude to produce adverse health consequences, and is associated with increased morbi–mortality. BMI is the most frequently used diagnostic tool in the current classification system of obesity. It has the advantage that a subject’s height and weight are easy and inexpensive to measure. Overweight is defined as a BMI between 25.0 and 29.9 kg/m2 and obesity as a BMI ≥30.0 kg/m2</su...

Background: Alpelisib is an α-selective PI3K inhibitor indicated for the treatment of postmenopausal women and men with hormone receptor-positive (HR+), human epidermal growth receptor 2-negative (HER2–), PIK3CA-mutated locally advanced or metastatic breast cancer following disease progression or after endocrine therapy. Hyperglycemia is the most common adverse event (up to 60%) associated with its use. It occurs more frequently and lasts longer in patients with pred...

Objectives and methods: The mechanism that explains the different weight response to various treatments in obese type 2 diabetes (DM2) patients, compared to those without diabetes, is still unknown. In order to establish the weight response to Roux-en-Y Gastric Bypass (RYGB), 268 patients with morbid obesity (IMC 45.4±0.4 kg/m2) were classified by OGTT as having normal glucose tolerance (Grupo A. n=107), prediabetes (Grupo B. n=96) an...

Background: There is a clear relationship between obesity and carbohydrate metabolism alterations (CMA), such as impaired glucose tolerance (IGT) and T2D. OGTT is used for the diagnosis of those alterations, but is not performed in case of normal fasting glucose values (NFG). Moreover, BMI underestimates the diagnosis of obesity and body composition alteration can be crucial to the development of abnormal carbohydrate metabolism. This study aimed to examine the discriminating ...

Obstructive sleep apnoea (OSA) is very common in severe obese patients and has been related to insulin resistance (IR) and hyperleptinemia, and these findings may have effects on food behavior and obesity complications. In order to explore this relationship and the role of sex we have studied 531 patients with morbid obesity (BMI 42.8+6.5 kg/m2). A full polysomnographic study and glucose, insulin and leptin measurements as well as air displacement plethysmography we...

The metabolic syndrome (MS) is a pathological entity that carries a high cardiovascular risk, and whose risk factors may occur at an early age. No data are available in our area on the influence of age on the prevalence of MS.Objectives: To determine the prevalence of MS in our area, by age group and compare the frequency of occurrence of MS in young adults (<40 years) (J) and mature adults (>40 years) (M).Methods: Observat...

Aim: Non-alcoholic fatty liver disease (NAFLD) and type 2 Diabetes (T2D) are common conditions that frequently co-exist. Studies have shown an increase likelihood of micro and macrovascular complications in this population, as well, as an increased risk of developing more severe forms of liver disease. The aim of this study was to identify diabetic complications in patients with both diseases and search for an association with liver stiffness assessed by Liver Elastography (LE...

69-year-old male, with a history of bipolar disorder under treatment, smoker and high blood pressure. He is referred for left adrenal injury detected incidentally by secondary hypertension study. Abdominal CT shows a mass of 67.7×51.8×52.3 mm in the left adrenal area, with radiological characteristics of malignancy and aggressive behavior, contacting the left renal pole and upper splenic pole, compatible with adrenal carcinoma vs. metastasis. The functional study is ...

Nutritional status has an important effect on the progression of any disease, not only in hospitalized patients, even more in ambulatory patient of primary care. Although there are many systems of evaluating nutritional status, they are costly and subject to variability amongst individuals. The Medicine Laboratory can correctly perform a nutritional evaluation in a quick an efficient manner.Objective: Analyze the nutritional status by CONUT nutritional e...